Highlight | Molecular mechanisms
Human pathogenic bacteria such as Yersinia pestis and Pseudomonas aeruginosa, inject their toxins using a macromolecular nano-machine, the type III secretion system. Researchers at our institute recently discovered in P. aeruginosa that it was possible to use antibodies directed against the translocation pore of this secretion system in order to inhibit it. In this article these researchers show firstly that the constitutive protein of the translocation pore assembles itself into oligomers takinf the form of rings. The authors define on the other hand, at the molecular level, the region of the protein involved in bacterial toxicity. These findings will help to better target future developments of new vaccines or anti-microbial agents.
Quinaud M, Chabert J, Faudry E, Neumann E, Lemaire D, Pastor A, Elsen S, Dessen A and Attree I
Journal of Biological Chemistry, 2005
Quinaud M, Ple S, Job V, Contreras-Martel C, Simorre JP, Attree I and Dessen A
Proceedings of the National Academy of Sciences USA, 2007
Goure J, Broz P, Attree O, Cornelis GR and Attree I
Journal of Infectious Disesases, 2005
Gebus C, Faudry E, Bohn YST, Elsen S and Attree I
Journal of Biological Chemistry, 2008
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.