Press release | Cytoskeleton
Due to the design of a device mimicking a cell skeleton or cytoskeleton, researchers from the CEA CNRS and Université Joseph-Fourier could for the first time decipher some of the organizational laws defining the architecture of cells. These investigators have shown that motor molecules, the myosins, were responsible for the selective contraction of certain intracellular structures formed by actin, an abundantly protein in the cells. The highlight mechanism allows to understand how the generation of forces inside the cells can be locally modulated in a very accurately way. These results open new perspectives, especially for the understanding of dysfunctions observed in some serious diseases like cancer.
This work is published online June 7 by the journal Science.
Reymann AC, Boujemaa-Paterski R, Martiel JL, Guérin C, Cao W, Chin HF, De La Cruz EM, Théry M and Blanchoin B
Actin network architecture can determine myosin motor activity.
Science AAAS, 2012
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.