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Junior team leader positions


Published on 7 April 2017



The “Biosciences and Biotechnology Institute of Grenoble” (BIG) develops multidisciplinary approaches with the aim of deciphering the molecular mechanisms behind major biological processes. Thanks to its environment and the state-of-the-art technological platforms available, BIG explores the dynamic architectures of “Life” at scales ranging from the atomic to the whole organism. This multi-scale knowledge allows us, with our academic and industrial partners, to develop new Life-inspired devices. The technological breakthroughs made possible by this bio-inspired approach should lead to promising returns which will improve health and promote greater respect for our environment.

BIG is currently seeking junior group leaders to set up research teams with starting grants such as ATIP-Avenir and/or ERC. Successful candidates will be supported by BIG to obtain permanent positions at one of the major French research organizations. The research programs carried out should be relevant to the BIG scientific project, with the aim to seek collaborations inside the institute and within the Grenoble scientific environment. Applicants are expected to propose an independent research project within the 3 profiles described below. Candidates with excellent track records are invited to submit a single file including their CV, the complete list of publications, a summary of scientific achievements, proposed research (maximum 3 pages), and contact details for three referees to Jérôme GARIN, ideally before May 15th 2017.

- Young investigator with a strong expertise in medicinal chemistry to develop new concepts in drug delivery for cancer therapy and infectious disease treatment. The candidate should perform an independent research program extending from the design and synthesis of novel molecules to in vivo assays. The applicant will benefit from the strong expertise present at BIG in the fields of synthetic chemistry and cell biology and have access to different platforms (high throughput screening, RMN, Mössbauer) and state of the art instrumentation (X-ray crystallography, imaging techniques).

- Young investigator expert in bioinspired multicellular 3D architectures, such as human organoids. The candidate will benefit from state-of-the-art environment in microfabrication, microfluidic, 3D culture of human cells, live cell imaging technologies, RNAi-based high content and high throughput screening, proteomics, to develop her/his own project research using human organoids to decipher basic principles that govern organ development, function and disease. On a longer term this project could also help the discovery of new biomarkers and therapeutic targets in diseases, particularly in oncology. Eventually, these models will optimize drug development while reducing the use of animal models. The candidate should have an excellent experience in cell biology, particularly stem cell, 3D cultures of mammalian cells, but also in micro technologies, microfluidic and microfabrication.

- Young investigator with a strong interest in studying the molecular and architectural organization of photosynthetic membranes in unicellular phototrophs, and their dynamic responses to environmental stresses (e.g. nutrient starvation, light, oxidative stress and heavy metals pollution). Using structural cell biology and single-cell physiology, she/he will reassess structural features of chloroplasts, offering new ideas on how to optimize their photosynthesis, and illustrate possible molecular responses to future ocean environments. Thus, her/his work will be relevant to climate changes, environment and possible biotechnology applications of photosynthetic organisms. The applicant should have excellent record in microscopy/single cell physiology, including cryo preparation, tomography, investigation of physiology/metabolism.


Candidates with excellent track records are invited to submit a single file including their CV, the complete list of publications, a summary of scientific achievements, proposed research (maximum 3 pages), and contact details for three referees to Jérôme GARIN,  before September 15th 2017.

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